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KMID : 0364819870250030205
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Korean Journal of Microbiology
1987 Volume.25 No. 3 p.205 ~ p.211
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Characterization of Methionine Analogue-Resistant Mutant of Cephalosporium acremonium
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Lee, Kyoung/이경
Choi, Sang Ho/Lee, Jung Joon/Mheen, Tac Ick/최상호/이정준/민태익
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Abstract
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1
Cephalosporium acremonium MAR-80, a strain of methionine analogue-resistant mutant, showed good activity of sulfate utilization as only sulfur source. The effect of methionine on the sulfate uptake system was investigated by using Nat SO4 as a tracer in the resting cell system. From this result, it was revealed that sulfate permease of this strain was less repressed and/or less inhibited by methionine than parent type. This deregulation was due to low activity of met ionine uptake, which was operated by somewhat simple diffusion. From these studies, it could be anticipated that the improved productivity of cephalosporin C and lower dependence of cephalosporio C production on methionine were related to increased uptake rate of sulfate.
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